Short Bites: HIV Oral Health and COVID-19

The relationship between oral health and overall health has been well established for many comorbidities including diabetes and cardiovascular disease.

We are still learning about COVID-19 and how it affects people living with HIV. Based on limited data, people with HIV who are on effective HIV treatment have the same risk for COVID-19 as people who do not have HIV.

Older adults and people of any age who have serious underlying medical conditions might be at increased risk for severe illness. This includes people who have weakened immune systems. The risk for people with HIV getting very sick is greatest in

  • People with a low CD4 cell count, and
  • People not on effective HIV treatment (antiretroviral therapy or ART).

Several recent studies indicate that a potential relationship exists between oral health, specifically periodontal disease, and severity of COVID-19 symptoms. A summary of these studies is:

  • There is a potential link between SARS-CoV-2 and bacterial load, questioning whether bacteria may play a role in bacterial superinfections and complications such as pneumonia, acute respiratory distress syndrome and sepsis.
  • Bacteria that colonize the mouth are shed into the saliva. The pathogenic bacteria within the saliva can then be aspirated into the lower respiratory tract and cause or aggravate an infection.
  • Comorbidities at highest risk of COVID-19 complications also cause imbalances in the oral microbiome and increase the risk of periodontal disease.
  • In addition, high bacterial load in the mouth may exacerbate post-viral complications.

This stresses the importance of patients living with HIV maintaining good oral health and visiting their dentists on a regular basis. The below diagram illustrates how bacteria from the oral cavity and inflammatory cytokines have affected the lungs.

diagram illustrating how bacteria from the oral cavity and inflammatory cytokines have affected the lungs


Botros, Iyer. Ojcius, Is there an association between oral health and severity of COVID-19 complications? Biomedical Journal, Volume 43, Issue 4, 2020, Pages 325-327, ISSN 2319-4170,

Brian, Z., & Weintraub, J. A. (2020). Oral Health and COVID-19: Increasing the Need for Prevention and Access. Preventing chronic disease, 17, E82.

Sampson, V., Kamona, N. & Sampson, A. Could there be a link between oral hygiene and the severity of SARS-CoV-2 infections? Br Dent J 228, 971–975 (2020).

Viviana Pitones-Rubio, E.G. Chávez-Cortez, Angélica Hurtado-Camarena, Anna González-Rascón, Nicolás Serafín-Higuera, Is periodontal disease a risk factor for severe COVID-19 illness? Medical Hypotheses, Volume 144, 2020, 109969, ISSN 0306-9877,

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