Updates in Antiretroviral Treatment during Pregnancy: Dolutegravir in Late Pregnancy

Publish Date: 
Tuesday, September 25, 2018

Although DTG currently is not a desirable medication for women to take pre-conception (see Dolutegravir in Early Pregnancy: Updates on Possible Risk of Neural Tube Defects), findings from the DolPHIN study suggest that it may be a very useful agent for women who start ART during late pregnancy.

TargetHIV: New Name, New Look

Publish Date: 
Wednesday, September 12, 2018

It's easier than ever to stay on target. The Health Resources and Services Administration's (HRSA) Ryan White HIV/AIDS Program (RWHAP) technical assistance (TA) and training website has undergone a major update to make it easier for users to access tools and materials for the RWHAP. The website, formerly called TARGET Center, is now named TargetHIV. Beyond the name change, there have been multiple revisions and updates, including a new look, easier navigation, and decluttering of the content.

Dolutegravir + 3TC in Initial Therapy

Susa Coffey's picture
Publish Date: 
Tuesday, August 21, 2018

As we have commented in the past, initial ARV regimens consisting of 2 drugs tend to perform poorly in comparison with currently recommended 3-drug regimens. Yet, given toxicity concerns about some ARVs (particularly about tenofovir DF and abacavir) and cost concerns about 3-drug regimens, the search for a potent and tolerable 2-drug regimen has continued. At the recent International AIDS Conference in late July, data were presented

Darunavir/Cobicistat/FTC/TAF Coformulation Approved; More Data from EMERALD Switch Study

Susa Coffey's picture
Publish Date: 
Monday, August 20, 2018

The U.S. Food and Drug Administration has given approval to a coformulation of darunavir 800 mg/cobicistat 150 mg/emtricitabine 200 mg/tenofovir alafenamide (TAF) 10 mg, to be marketed under the brand name Symtuza. DRV/COBI/FTC/TAF constitutes a complete regimen for patients with susceptible HIV, and is the first protease inhibitor-containing single-tablet regimen (STR). The approval is specifically for initial HIV treatment and for

Practicing Cultural Humility to Transform Health Care

Publish Date: 
Thursday, June 21, 2018
Moving beyond culture competency to cultural humility acknowledges patients’ authority over their own lived experience

Health care delivery often involves a one-size-fits-all approach. As clinicians, we treat a patient with a particular diagnosis similar to the last patient we saw with the same diagnosis because it’s efficient—we think. But shifting that mindset is one of the best opportunities we have to help people truly thrive. An individual’s lived experience is rich, diverse, and complicated.

Possible Safety Issue with Dolutegravir during Pregnancy: Reports of Neural Tube Defects

Susa Coffey's picture
Publish Date: 
Wednesday, May 23, 2018

On May 18, 2018, the U.S. Food and Drug Administration and the World Health Organization announced that cases of neural tube defects have been reported in babies of women with HIV who were on treatment with dolutegravir at the time of conception and during early pregnancy. The information comes from an unplanned interim analysis of an observational study (the Tsepamo Study) of ART (dolutegravir/TDF/FTC or efavirenz/TDF/FTC) in pregnant women in Botswana.

Rifampin Drug-Drug Interactions with Newer Antiretrovirals (TAF, Bictegravir, Dolutegravir)

Publish Date: 
Wednesday, April 11, 2018

Treatment of tuberculosis (TB) in HIV-infected persons remains challenging, in part because of drug interactions between rifampin and some ARVs that may compromise antiretroviral therapy (ART). Three studies presented at CROI provide clinicians with additional guidance on


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