Non-Occupational Post-Exposure Prophylaxis (nPEP) Toolkit

This toolkit is a collaborative product of the AETC Program Rural Health Committee, the AETC National Clinician Consultation Center, the Georgia Department of Public Health, the International Association of Forensic Nurses, and the National Center for Medical-Legal Partnership. 


  • Start post-exposure prophylaxis (PEP) as soon as possible after a known or possible HIV exposure (occupational or non-occupational sexual and injection exposures)
  • These resources provide step-by-step instructions for the medical care of persons following possible sexual HIV exposure
  • The U.S. Food and Drug Administration (FDA) alerted the public on 5/18/18 that serious cases of neural tube birth defects have been reported in babies born to women living with HIV who were treated with dolutegravir prior to conception. Providers may call the PEPline at (888) 448-4911 if they have questions or need additional support.

Toolkit Materials

These materials were developed to be used in clinical settings to raise awareness and offer detailed guidance. Order free printed copies of the pocket guide or scroll pen. All additional materials can be downloaded and printed as needed. 

The State of nPEP in Rural America: Clinician Perspectives

ShareSpot: The AETC Blog

Patients to Policy Story

National Center for Medical-Legal Partnership: Patients-to-Policy Story Series

World AIDS Day 2017 PEP Interview with Dr. Donna Sweet

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