The national centers within the AETC Program serve unique roles within and beyond the AETC network.
- National Coordinating Resource Center: Works closely with the HRSA HIV/AIDS Bureau to coordinate cross-regional collaborative efforts. It manages this website, plans and executes the national Ryan White HIV/AIDS Program Clinical Conference. It also develops an online curriculum for clinical learners.
- National Clinician Consultation Center : Manages free clinical hotlines and warmlines for clinicians. Cares for people with HIV and related conditions such as hepatitis C and substance abuse.