Research Towards an HIV Cure

(Recorded 5/8/23) Although current therapy for HIV infection can be safe, simple, and durable, the burden of decades of continuous therapy remains, with the stigma and uncertainty of chronic HIV infection. Although current antiretroviral therapy (ART) can nearly eliminate viremia in patients with HIV infection, a small population of long-lived CD4+ T cells remains persistently infected and unrecognized by the immune system, with minimal expression of HIV genes or proteins. The persistence of quiescent HIV infection is a major obstacle to eradication and cure of HIV infection. New therapeutic approaches to this quiescent or latent state of HIV infection are needed. This presentation discusses research towards an HIV cure.