Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents


The guidelines address the following opportunistic infections: PCP, Toxo, Cryptosporidia, Microsporidia, TB, MAC, Bacterial Respiratory Disease, Bacterial Enteric Disease, Bartonella, Syphilis, Candida, Endemic Mycoses (Cryptococcosis, Histo, Cocci, Aspergillus) CMV, Non-CMV Herpes (HSV, VZV, HHV-8) HPV, HBV, HCV, PML/JCV, and Geographic OIs of Specific Consideration (Malaria, Penicilliosis, Leishmania, Chagas, Isospora).

Recommendations in this report cover:

  • Preventing exposure to opportunistic pathogens; 
  • Preventing disease; 
  • Discontinuing primary prophylaxis after immune reconstitution; 
  • Treating disease; 
  • When to start ART in the setting of an acute OI; 
  • Monitoring for adverse effects (including immune reconstitution inflammatory syndrome [IRIS]); 
  • Managing treatment failure; 
  • Preventing disease recurrence ("secondary prophylaxis" or chronic maintenance therapy); 
  • Discontinuing secondary prophylaxis after immune reconstitution; and 
  • Special considerations during pregnancy. 

Slide sets to accompany the guidelines are available from the National Coordinating Resource Center.

Check all that apply
Check all that apply

Add comment

Log in to post comments