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Initiating Treatment

Articles: 4

  • START-ing TEMPRANO: Early Initiation of Antiretroviral Therapy for HIV

    October 1, 2015

    The prevailing opinion among experts regarding the optimal CD4 T-cell count at which to start patients on antiretroviral therapy (ART) has shifted several times during the evolution of HIV treatment. These shifts reflect attempts to strike a balance between preventing HIV-associated illness and...

  • Adult and Adolescent Guidelines: Major Changes

    April 28, 2015

    • Susa Coffey, MD, AETC National Coordinating Resource Center, UCSF Center for HIV Information

    The U.S. Department of Health and Human Services has released new treatment guidelines for adults and adolescents, and these contain some important changes. Key among these is a major shakeup in the "Recommended Regimen Options" for initial therapy. 

    Efavirenz/TDF/FTC (Atripla) has...

  • Darunavir + Raltegravir without NRTIs: NEAT Study Results

    April 28, 2014

    • Susa Coffey, MD, AETC National Coordinating Resource Center, UCSF Center for HIV Information

    Over the past few years, numerous studies have examined the use of NRTI-sparing regimens in initial therapy. These regimens generally have not been as effective as standard regimens, for reasons that are not entirely clear, or have had higher rates of toxicity. Two small studies...

  • First-Line Therapy: Raltegravir, Darunavir, or Atazanavir?

    April 28, 2014

    • Susa Coffey, MD, AETC National Coordinating Resource Center, UCSF Center for HIV Information

    ACTG 5257 is a randomized open-label comparison of 3 ARV regimens for initial therapy: atazanavir + ritonavir (ATV/r), darunavir + ritonavir (DRV/r), or raltegravir (RAL), each in combination with fixed-dose tenofovir/emtricitabine.

    The 3 treatment groups (...