The Ending the HIV Epidemic (EHE) initiative is focusing on the approximately 50 jurisdictions (cities, states, and counties) where new HIV infections are most concentrated. These are shown below.

Each of the eight AETC regions has at least one EHE participating jurisdiction (listed below). The regional AETCs will support EHE activities in their regions with targeted training and technical assistance.
In addition, the two national AETCs are supporting the initiative and the AETC network. The NCCC is providing clinician-to-clinician consultation regarding nPEP, PrEP, and HIV testing, diagnosis, and management.
The NCRC is coordinating and developing resources for health care teams to utilize in providing cutting-edge, quality care to optimize health in people with HIV and reduce transmission in communities. The NCRC launched and maintains a mobile app, HIV Care Tools, featuring clinical reference tools and a national directory of training and consultation services.

MidAtlantic AETC
Maryland
- Baltimore City
- Montgomery County
- Prince George’s County
Pennsylvania
- Philadelphia County
District of Columbia
Midwest AETC
Illinois
- Cook County
Indiana
- Marion County
Michigan
- Wayne County
State of Missouri
Ohio
- Cuyahoga County
- Franklin County
- Hamilton County
Mountain West AETC
Washington
- King County
New England AETC
Massachusetts
- Suffolk County
Northeast/Caribbean AETC
New Jersey
- Essex County
- Hudson County
New York
- Bronx County
- Kings County
- New York County
- Queens County
Puerto Rico
- San Juan Municipio
Pacific AETC
Arizona
- Maricopa County
California
- Alameda County
- Los Angeles County
- Orange County
- Riverside County
- Sacramento County
- San Bernadino County
- San Diego County
- San Francisco County
Nevada
- Clark County
South Central AETC
State of Arkansas
Louisiana
- East Baton Rouge Parish
- Orleans Parish
Oklahoma
Texas
- Bexar County
- Dallas County
- Harris County
- Tarrant County
- Travis County
Southeast AETC
State of Alabama
Florida
- Broward County
- Duval County
- Hillsborough County
- Miami-Dade County
- Orange County
- Palm Beach County
- Pinellas County
Georgia
- Cobb County
- DeKalb County
- Fulton County
- Gwinnett County
State of Kentucky
State of Mississippi
North Carolina
- Mecklenburg County
State of South Carolina
Tennessee
- Shelby County